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Insulin Glulisine

About Insulin Glulisine

Insulin Glulisine is rapid-acting insulin for the treatment of diabetes mellitus in both children (above six years of age) and adults. The active ingredient in Insulin Glulisine is insulin glulisine. Insulin Glulisine is a recombinant human insulin analogue that is equipotent to regular human insulin. Insulin glulisine has a more rapid onset of action and a shorter duration of action than regular human insulin. Diabetes is a lifelong condition that causes a person's blood sugar level to become too high.

Insulin Glulisine is a fast-acting insulin that works rapidly to normalise blood sugar levels after a meal. It typically begins working within 10-20 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Due to this short action, Insulin Glulisine should normally be taken in combination with intermediate-acting or long-acting insulin preparations. Insulin Glulisine works by ensuring rapid and consistent sugar control. Insulin Glulisine is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Prevents the risk of having severe complications of diabetes.

The primary role of insulin and insulin analogues, including insulin glulisine, is glucose metabolism control. Insulin lowers blood glucose levels by stimulating peripheral glucose uptake, particularly skeletal muscle and fat, and inhibiting hepatic glucose production. Insulin glulisine takes effect about twice as fast as regular human insulin and completes the glucose-lowering effect about 2 hours earlier than regular human insulin.

Your doctor will advise you on how to use Insulin Glulisine. It should be administered at least 0-15 minutes before or soon after meals. The common side effects of Insulin Glulisine are hypokalaemia (low potassium), hypoglycaemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin), which may occur at the injection site. Most of these side effects of Insulin Glulisine do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Insulin Glulisine of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take Insulin Glulisine if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with Insulin Glulisine, you should take a healthy diet, exercise regularly, and maintain weight as your doctor advises. Insulin Glulisine is a cold chain medicine, so it must be stored in the refrigerator between 2-8 degrees Celsius; otherwise, its efficiency might get lost. Do not store it in the freezer of the fridge.

Uses of Insulin Glulisine

Diabetes (Type 1 diabetes mellitus, Type 2 diabetes mellitus)

Medicinal Benefits

The primary role of insulin and insulin analogues, including insulin glulisine, is glucose metabolism control. Insulin lowers blood glucose levels by stimulating peripheral glucose uptake, particularly skeletal muscle and fat, and inhibiting hepatic glucose production. Insulin Glulisine works by ensuring rapid and consistent sugar control. Insulin Glulisine is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver. Insulin Glulisine helps in improving the glycaemic control, which in turn decreases the risk of progression of complications of diabetes like damage of the retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer and others. Besides this, Insulin Glulisine can be safely prescribed to the diabetic mother during pregnancy and lactation.

Directions for Use

Insulin Glulisine is administered at least 15 minutes before a meal or 20 minutes after starting a meal in the abdomen or thigh region. It can be also given intravenously (IV) with 0.9% sodium chloride infusion. However subcutaneous injection of Insulin Glulisine in the abdomen region ensures faster absorption compared to other injection sites. Insulin Glulisine is usually given once or twice daily when both rapid and prolonged effect of insulin is desired. In the initial requirement, the dose requirement is usually between 0.3 and 1.0 IU/kg per day. An injection of Insulin Glulisine should be followed within 30 minutes by a meal or snack containing sugar/glucose (carbohydrates). If you are not well trained to self-administer Insulin Glulisine, ask healthcare professional to administer it. Procedure for self-injecting insulin: • You should wash your hand first before injecting insulin. • Then roll the insulin bottle and wipe the bottle top. • Now pull the plunger of the syringe down to an appropriate number of units your doctor has prescribed. • Push the needle into the bottle and push syringe plunger down. • Now once again pull the plunger down to an appropriate number of units as prescribed by the doctor. • Pick the injection site and wipe it with an alcohol swab. Now, pinch up the skin and push the needle into the skin and then push the plunger in. • The needle should be kept under the skin for at least 6 seconds to make sure the entire dose is injected. • After injecting the insulin pull out the needle and dispose of the syringe safely. And then you can have a meal or snack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Insulin Glulisine

  • Injection site reactions (such as reddening, unusually intense pain on injection, itching, hives, swelling or inflammation)
  • Hypoglycaemia (low blood sugar level)
  • Hypokalaemia (low potassium)
  • Lipodystrophy (fat deposition under the skin)
  • Rash
  • Pruritus (itchy skin)

Patients Concern

Disease/Condition Glossary

Diabetes: Diabetes is a chronic or lifelong disease that prevents the body from utilizing insulin properly. Insulin is the hormone that controls sugar levels in the blood. Diabetes is a condition in which blood glucose levels are above normal. It is of two types, namely: type-1 and type-2 diabetes. Type-1 diabetes is a condition in which the pancreas produces little or no insulin. Type-2 diabetes affects the way the body processes sugar. Symptoms of diabetes include lack of energy, tiredness, frequent urination, excess thirst, dry mouth, blurry vision, constant hunger, weight loss, and itchy skin.

FAQs

Insulin Glulisine can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether Insulin Glulisine can be given to you or not depending on your present condition. Insulin Glulisine should be avoided in patients who are allergic to Insulin Glulisine or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

Insulin kept out of the refrigerator will not poison you or even make you sick. It just means that your insulin will not work as well or deliver its full potential dose. In simple terms, if your blood sugar is high, and you use the insulin that has been kept out, your blood sugar may not be lowered.

Insulin is released from the beta cells in your pancreas in response to the rise in glucose in your bloodstream. After you have consumed a meal, any carbohydrate you have eaten is broken down into glucose and transferred into the bloodstream. The pancreas detects this rise in blood glucose and starts to secrete insulin.

Habitual moderate coffee drinking has actually been associated with increased insulin sensitivity and lowered risk for type 2 diabetes. But in acute and high doses, caffeine can decrease insulin sensitivity and raise plasma insulin levels.

Insulin is released from the beta cells present in your pancreas in response to rising glucose in your bloodstream. The pancreas detects this rise in blood glucose and starts to secrete insulin.

A hard-boiled egg is a handy high-protein snack when you have diabetes. Your protein will help keep you full without impacting your blood sugar. Protein not only slows down digestion, but it also slows down the absorption of glucose. If you have diabetes, this is very beneficial.

Pramlintide, Ethanol (Alcohol) and Macimorelin have got serious interactions with Insulin Glulisine. So, do not take these medicines with Insulin Glulisine.

Available Medicines for

Insulin Glulisine

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